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In a 2010 study, the performance of an Olympus AU2700 plus was evaluated, using allowable maximum bias and imprecision values from the Ricos et al biologic variation database. Which got us to thinking, what would the metrics be if the Ricos specifications for allowable total error were used? For that matter, what if Rilibak or CLIA quality requirements were used?
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In a 2008 issue of Annals of Clinical Biochemistry, a study looked a seven different 25-hydroxyvitamin D methods, compared with liquid chromatography-tandem mass spectometry. Using quality requirements developed by and derived from Stockl, Sluss, and Thienpont, we examine this methods with Sigma-metric analysis.
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In a 2009 issue of Annals of Clinical Biochemistry, a study takes on two Point-of-Care HbA1c devices using two different reference methods. Both POC methods are standardized to the IFCC reference system and aligned to DCCT standards via the National Glycohemoglobin Standardization Program (NGSP). Both reference methods are also standardized against the IFCC reference method and traceable to DCCT and NGSP. If everything is standardized and traceable, there can't be any problems, right?
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A poster at the 2009 AACC conference evaluated the performance of the new VITROS 5600 system. VITROS is well known for its MICROSLIDE and MICROTIP technologies. We review the data and generate graphic analysis.
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A poster at the IFCC conference applied Sigma-metric analysis to a number of hematology methods, including differential parameters, on the Sysmex xt 1800i. Interestingly, they chose Biologic-based quality requirements, not the usual CLIA goals. We review the data and generate some graphic analysis.
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